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Fast, compact and label-free electrical detection of live and dead single cells

TitoloFast, compact and label-free electrical detection of live and dead single cells
Tipo di pubblicazionePresentazione a Congresso
Anno di Pubblicazione2013
AutoriNing, Y., Multari C.R., Luo X., Merla Caterina, Palego C., Cheng X., and Hwang J.C.M.
Conference Name2013 IEEE MTT-S International Microwave Workshop Series on RF and Wireless Technologies for Biomedical and Healthcare Applications, IMWS-BIO 2013 - Proceedings
Parole chiaveBio-impedance, Biological cells, Biosensors, Cell manipulation, Cells, cytology, Electrical detection, Health Care, Impedance match, Microfluidics, Microsensors, molecular biology, Reflectometry, Single-cell level, Solution effects, Wireless telecommunication systems
Abstract

Using a novel broadband microchamber, electrical detection of live and dead single cells was demonstrated. Tests on Jurkat cells showed that live cells had lower resistance but higher capacitance than that of dead cells. The test results were compared with the limited literature on broadband electrical detection of single cells and the discrepancies, both qualitative and quantitative, were discussed. These results indicate that, while broadband electrical detection at the single-cell level is becoming feasible, many challenges remain in impedance match, calibration, sensitivity, cell manipulation, solution effect and modeling. © 2013 IEEE.

URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84897494841&doi=10.1109%2fIMWS-BIO.2013.6756250&partnerID=40&md5=de3bc745f6b9d81acec663e84bb06f1c
DOI10.1109/IMWS-BIO.2013.6756250
Citation KeyNing2013