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An in vivo exposure-system for wide-band electric pulses

TitleAn in vivo exposure-system for wide-band electric pulses
Publication TypePresentazione a Congresso
Year of Publication2018
AuthorsMerla, Caterina, Apollonio F., Paffi A., Vernier P.T., and Liberti M.
Conference NameIET Conference Publications
KeywordsAnimals, Bio-electromagnetics, Dielectric materials, dosimetry, Efficiency, Electric fields, Electric pulse, Electromagnetic Fields, Electropermeabilization, Exposure conditions, In-vivo experiments, Induced electric fields, Irradiated materials, Microstrip antennas, Monopolar patch antenna, Monopole antennas, Slot antennas
Abstract

In this paper, the dosimetry of small animals arranged on a monopolar patch antenna for bioelectromagnetic experiments is reported. Numerical simulations were carried out to verify the matching of the antenna in the presence of a dielectric box to accommodate the small animals. This strategy, reducing the dielectric differences between the various irradiated materials, improves largely the efficiency of the setup. The induced electric field in the biological samples reached tens of V/m for an input voltage of 1 V, which is one of the highest efficiency obtained so far for these types of exposure setup. A very short electric pulse (on-time duration of 1 ns) is transferred mostly undistorted to the biological sample guaranteeing controlled experimental exposure conditions. Optimization of the positioning of the small animals was also analyzed. Our setup can be used to study effects of short and intense electric pulses in vivo only poorly addressed so far. © 2018 Institution of Engineering and Technology.All Rights Reserved.

URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85057327314&partnerID=40&md5=f096ac4800057f02bb5b93b36138e8b3
Citation KeyMerla2018