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A computational design of a versatile microchamber for in vitro nanosecond pulsed electric fields experiments

TitoloA computational design of a versatile microchamber for in vitro nanosecond pulsed electric fields experiments
Tipo di pubblicazioneArticolo su Rivista peer-reviewed
Anno di Pubblicazione2017
AutoriCasciola, M., Liberti M., Denzi A., Paffi A., Apollonio F., Casciola M., Denzi A., and Merla Caterina
RivistaIntegration, the VLSI Journal
Volume58
Paginazione446-453
Parole chiaveApplicators, Biological samples, Computational design, Electric fields, Experimental repeatabilities, High voltage, Microfluidics, Multicell, Nanosecond pulsed electric fields, Pulse propagation, Real time monitoring
Abstract

The emergence of nanosecond pulsed electric fields (nsPEFs) for intracellular manipulation experiments requires the use of specific miniaturized applicators. We propose the design of a versatile nsPEFs applicator, based on microwave propagating systems, suitable for in vitro exposure to undistorted 1–3 ns pulses in single and multi-cell experiments. Further features of the proposed devices are: high efficiency, microfluidic integration, real time monitoring of the biological sample and of the pulse propagation. Generally, these features can be considered as specific requisites for nanosecond applicators, to ensure experimental repeatability and reproducibility, when propagation related phenomena cannot be considered negligible. © 2017 Elsevier B.V.

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URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85017159548&doi=10.1016%2fj.vlsi.2017.03.005&partnerID=40&md5=873cd073722df01dab3e7a8db2c93aec
DOI10.1016/j.vlsi.2017.03.005
Citation KeyCasciola2017446